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Tacrolimus (Generic) 1mg 100 Capsules

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Product info

Tacrolimus (Generic) 1mg 100 Capsules


Tacrolimus Sandoz®

tacrolimus capsules

Consumer Medicine Information


This leaflet answers some common questions about Tacrolimus Sandoz.
It does not contain all the available information. It does not take the place of talking to your doctor or pharmacist.
All medicines have risks and benefits. Your doctor has weighed the risks of you taking this medicine against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist. Keep this leaflet with the medicine.

You may need to read it again.


This medicine is used in combination with your liver, kidney, lung or heart transplant.
It contains the active ingredient tacrolimus.
Tacrolimus belongs to a group of medicines called macrolide lactones.
You have been given a new transplanted liver or kidney, lung or heart from another person because your own was no longer healthy. Your body recognises that this new organ is different from your organs and will try to reject it by attacking it in the same way that it would attack germs that enter your body. This could make you become ill again.
Tacrolimus Sandoz, which is an immunosuppressive agent, works by stopping this attack; it is very important to take Tacrolimus Sandoz given to you by your doctor regularly so that your new liver, kidney, lung or heart will not be attacked or rejected.

Ask your doctor if you have any questions about why this medicine has been prescribed for you.

Your doctor may have prescribed it for another reason.
This medicine is available only with a doctor’s prescription.


When you must not take it

Do not take this medicine if you have an allergy to:

• tacrolimus, the active ingredient, or to any of the other ingredients listed at the end of this leaflet under Product description
• any other macrolides (these are antibiotics of the erythromycin family, e.g. Eryc, EES, Klacid, Zithromax, Rulide or Biaxsig).

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Some of the symptoms of an allergic reaction may include:
• shortness of breath
• wheezing or difficulty breathing
• swelling of the face, lips, tongue or other parts of the body
• rash, itching or hives on the skin.

Do not take this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to take it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. Tell your doctor if you are pregnant or plan to become pregnant or are breastfeeding.

Your doctor can discuss with you the risks and benefits involved.

Tell your doctor if:

• you are using oral contraceptives
• you are receiving cyclosporin immunosuppressive therapy.

If you have not told your doctor about any of the above, tell them before you start taking

Tacrolimus Sandoz.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including any that you get without a prescription from your pharmacy, supermarket or health food shop.

This is particularly important for Tacrolimus Sandoz because there are some specific medicines that could alter its effectiveness and safety.
Some medicines and Tacrolimus Sandoz may interfere with each other. These include:
• St John’s Wort (hypericum perforatum), a herbal preparation which is capable of decreasing tacrolimus blood levels
• antifungal agents such as ketoconazole, fluconazole, itraconazole, voriconazole
• erythromycin (macrolide antibiotic)
• HIV protease inhibitors (e.g. ritonavir)
• clotrimazole
• clarithromycin
• josamycin
• nifedipine
• nicardipine
• diltiazem
• verapamil
• danazol
• ethinylestradiol
• omeprazole
• nefazodone

Tacrolimus Sandoz® 2

• rifampicin
• phenytoin
• cyclosporin
• steroid-based contraceptives
• potassium sparing diuretics (e.g. amiloride, triamterene or spironolactone)
• live attenuated vaccines.
These medicines may be affected by Tacrolimus Sandoz or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines.
Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.


Follow all directions given to you by your doctor or pharmacist carefully.

They may differ from the information contained in this leaflet.

If you do not understand the instructions, ask your doctor or pharmacist for help.

How much to take

Your dose will be calculated according to your weight, age and medical condition. As your health and the function of your new liver or kidney, lung or heart can be affected by how much medicine you take, it is normal that your doctor collects samples of blood and urine at regular intervals. This is in order to test whether your medicine requires adjustment.

Ask your doctor or pharmacist if you are unsure of the correct dose for you.

They will tell you exactly how much to take.

Follow the instructions they give you.

If you take the wrong dose, Tacrolimus Sandoz may not work as well and your problem may not improve.

You must never change the dose yourself even if you are feeling better.

It is very important that you keep taking this medicine so that your body will not reject your new liver, kidney, lung or heart.

How to take it

Take the capsule from the blister pack and swallow it whole with plenty of water.

Do not take this medicine with grapefruit juice.

Grapefruit juice contains substances that interfere with the action of Tacrolimus Sandoz.

When to take Tacrolimus Sandoz

Food reduces the absorption of Tacrolimus Sandoz so the capsules should be taken at least 1 hour before or 2 to 3 hours after a meal.
The total daily amount should be divided and taken in two doses (e.g. morning and evening).

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How long to take Tacrolimus Sandoz

Continue taking your medicine for as long as your doctor tells you.

It is important to keep taking your medicine even if you feel well.

If you forget to take it

Take your dose as soon as you remember, and continue to take it as you would normally.
If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to.

Do not take a double dose to make up for the dose that you missed.

This may increase the chance of you getting an unwanted side effect.
If you accidentally take a larger dose than recommended, tell your doctor immediately.
If you have missed more than one dose, or if you are not sure what to do, ask your doctor or pharmacist. If you have trouble remembering to take your medicine, ask your pharmacist for some hints.

If you take too much (overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone Australia 13 11

26 or New Zealand 0800 POISON or 0800 764766) for advice, or go to Accident and Emergency at the nearest hospital, if you think that you or anyone else may have taken too much Tacrolimus Sandoz. Do this even if there are no signs of discomfort or poisoning.

You may need urgent medical attention.


Things you must do

Always follow your doctor’s instructions carefully.

Tacrolimus Sandoz suppresses your immune system by lowering your body's immune defence system. This increases your risk of skin cancer and other cancers while taking Tacrolimus Sandoz. Always protect yourself from the sun, wear sunscreen, a hat and protective clothing.

If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Tacrolimus Sandoz.

Tell any other doctors, dentists and pharmacists who treat you that you are taking this medicine.

If you become pregnant while taking this medicine, tell your doctor immediately.

Keep all of your doctor’s appointments so that your progress can be checked.

Your doctor may collect samples of blood and urine at regular intervals to make sure the medicine is working, to prevent unwanted side effects and to test whether your medicine requires adjustment.

Tacrolimus Sandoz® 4

Things you must not do

Do not take Tacrolimus Sandoz to treat any other complaints unless your doctor tells you to. Do not give your medicine to anyone else, even if they have the same condition as you.

Things to be careful of

Be careful driving or operating machinery until you know how Tacrolimus Sandoz affects you. This medicine may cause visual or nervous disturbances in some people. If affected, do not drive or operate machinery or do anything else that could be dangerous.


Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking

Tacrolimus Sandoz.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical attention if you get some of the side effects.

Do not be alarmed by the following lists of side effects. You may not experience any of them. Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor or pharmacist if you notice any of the following and they worry you:

• tiredness, lack of energy
• stomach upset, including nausea (feeling sick), vomiting, loss of appetite, diarrhoea, stomach cramps
• tremor (shaking)
• headache
• feeling depressed (sad)
• sleeping difficulties
• blurred vision or sensitive to light
• muscle cramps, tenderness or weakness.
These are mild side effects of the medicine and are short-lived.

If any of the following happen, tell your doctor immediately or go to Accident and Emergency at your nearest hospital:

• signs of allergy such as rash, itching or hives on the skin; swelling of the face, lips, tongue or other parts of the body; shortness of breath, wheezing or troubled breathing
• diabetes / increased blood sugar
• swelling, numbness or tingling (pins and needles) in your hands and feet
• constant "flu-like" symptoms such as chills, sore throat, fever, aching joints, swollen glands, or any other signs of infection, or yellowing of the skin and/or eyes (jaundice) often accompanied by generally feeling unwell (for example, tiredness, lack of energy, loss of appetite, nausea and vomiting, pain in the abdomen)
• unusual bleeding or bruising, or new lumps or moles, or changes to existing moles, anywhere on the body
• palpitations, abnormal heart rhythms, chest pain or high blood pressure
• swelling of the eyelids, hands or feet due to excess fluid
• a change in the amount of urine passed or in the number of times you urinate, pain on urinating, or

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other kidney problems
• symptoms of anaemia, such as shortness of breath, tiredness or dizziness
• seizures (fits)
• buzzing or ringing in the ears, difficulty hearing.
The above list includes very serious side effects. You may need urgent medical attention or hospitalisation.

Tell your doctor or pharmacist if you notice anything else that is making you feel unwell.

Other side effects not listed above may also occur in some people.



Keep your medicine in the blisters until it is time to take them. If you take it out of its original container it may not keep well.
Keep your medicine in a cool dry place where the temperature stays below 30°C.
After opening of the aluminium wrapping, store below 25°C and use within twelve months. Do not use after printed expiry date.
Do not store Tacrolimus Sandoz or any other medicine in the bathroom or near a sink. Do not leave it on a window sill or in the car.
Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


If your doctor tells you to stop taking this medicine or the expiry date has passed, ask your pharmacist what to do with any medicine that is left over.


Tacrolimus Sandoz comes in three types of capsules: Tacrolimus Sandoz 0.5mg – White and ivory opaque capsule. Tacrolimus Sandoz 1mg – White and light brown opaque capsule. Tacrolimus Sandoz 5mg – White and orange opaque capsule.
Available in packs of 100 (0.5mg/1mg) or 50 (5mg) capsules.


Active ingredients:
• Tacrolimus Sandoz 0.5mg – 0.5mg tacrolimus
• Tacrolimus Sandoz 1mg – 1mg tacrolimus
• Tacrolimus Sandoz 5mg – 5mg tacrolimus

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Inactive ingredients:
• hypromellose
• lactose
• croscarmellose sodium
• magnesium stearate
• titanium dioxide
• sodium lauryl sulfate
• sorbitan monolaurate
• gelatin
• iron oxide yellow (0.5mg & 1mg capsule only)
• iron oxide red (1mg & 5mg capsule only)
• iron oxide black (1mg capsule only).
This medicine does not contain sucrose, gluten, tartrazine or any other azo dyes.


Sandoz Pty Ltd
ABN 60 075 449 553
19 Harris St
Pyrmont NSW 2009
Tel: 1800 634 500
Novartis New Zealand Ltd Private Bag 65904 Mairangi Bay Auckland 0754
New Zealand
Tel: 0800 354 335
This leaflet was prepared in October 2011.

Australian Register Numbers

0.5mg capsules: AUST R 153744
1mg capsules: AUST R 153745
5mg capsules: AUST R 153746

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Delivery info

Please note that Public Holidays will add on extra delivery time for orders

SuperPharmacy orders will be packaged in plain, impervious packaging that is unmarked for security and privacy reasons. Orders will be dispatched as soon as possible once payment is received. 

We will dispatch most orders within business day from Monday to Friday, assuming all items are in stock. All other orders will be dispatched as quickly as possible thereafter.

For Orders containing prescription items please see the prescription processing procedure.


Australia Wide shipment details

We offer Standard Shipping for $4.95** with approximately 4-8 business days of transit time based upon your location within Australia.*

We also offer an Express Delivery Service for $10.95** with approximately 1-3 business days of transit time based upon your location within Australia.*

All Australian orders $99 or more in value will qualify for FREE Standard Shipping or Express Delivery at $7.95

Any orders that contain an item that requires Cold-Chain Shipping will incur a $10.95 Express Delivery Fee. This will overwrite any other thresholds.

Any orders over 5kgs will have our Online Team be in contact with further information regarding shipping.

All orders of Prescription items will receive FREE Delivery regardless of order value.

*These estimations are based upon transit time once dispatched from our locations. Please note our couriers do not operate on weekends and public holidays.

**These delivery costs do not represent orders that we consider 'Bulk Orders'.  Bulk Orders will have our Online Team be in touch in order to discuss appropriate shipping costs. For clarification on what we classify as a 'Bulk Order', refer to our terms and conditions or give us a call.


Sending a Prescription to SuperPharmacy.

When you purchase prescription medication online with SuperPharmacy, we need a valid script in our possession before we can dispatch your medications to you. 

For Electronic Prescriptions, it is now as easy as sending your Token to epharmacist@superpharmacy.com.au.

For Paper Prescriptions, we still require the physical paperwork in our possession, so they can only be processed once we physically receive your prescription paperwork. Prescription product orders will be dispensed and dispatched on the business day the prescription or valid repeat authorisation is received at the SUPERPHARMACY registered premises. Please send your prescription paperwork to the appropriate store

NSW, ACT and TAS:  SUPERPHARMACY PO Box 1877 Hornsby Westfield 1635

QLD or NT: SuperPharmacy 5/17 Billabong St, Stafford QLD, 4053

SA: SuperPharmacy 41 Hindley street Adelaide, SA 5000

VIC: SuperPharmacy 92 Lygon Street East Brunswick VIC 3057

WA: SuperPharmacy 259 Walcott St, North Perth WA 6006


Can I send a photo of my Script?

A photo is only valid for Electronic Prescriptions. For traditional Paper Prescriptions, we will need you to post the script to us as highlighted above.

Postage and handling for international orders

We do not currently deliver outside of Australia 

Returns & exchanges

How Do Returns & Refunds Work?

We are happy to offer refunds or exchanges on any item (excluding restricted items*) that you have purchased from us.

Important: You are not entitled to, or guaranteed, a refund for Change of Mind returns. They will be processed at our discretion. We reserve the right to charge a restocking fee for Change of Mind returns.
You will be responsible for the cost of shipping to return goods to us unless we specify that we will cover the cost.

Note: Legislation prohibits us from accepting Prescription Items for refund or exchange.


All we ask is that you follow the below to qualify:

  1. Check your products as soon as you receive delivery. Ensure the correct items have been sent, and nothing is damaged or in an unusable condition.
  2. Contact us within 30 days from your order date (7 days for damaged/incorrect items).

How We Handle Them:

Change of Mind

  • If you've had a change of mind about an item you have ordered, we'll need to receive it back to us unopened and unused, in the original packaging.

Faulty Item

  • If the item you have received is faulty, please contact us with a detailed description of the product fault, alongside a photo if possible.


Allergic Reaction

  • In the rare instance you've had an allergic reaction to a product, please discontinue use of the product immediately. We may reach out for further information on the reaction.

Allergy returns must be less than 20% used upon arrival back to us.

Incorrect / Damaged Items

  • If you have received an item that isn't what you ordered, or it arrived damaged, please take a photo and contact us within 7 days of delivery. 

Please don't dispose of the item without informing us.


The Process:

  1. Contact Us

    • To start a return, please send your request to customerservice@superpharmacy.com.au. Make sure we have received & acknowledged your request before you send the item back to us.
  2. Instructions

    • A Customer Service Team Member will then review your request, and be in touch with some further information. Should your request be approved, they will supply a return address for you to post the item back to us, and instructions on how to do so.
  3. Drop Off At Your Post Office

    • Once you have received the returns address and packaged and labelled your box as instructed, all you need to do is drop off the parcel at your local Post Office. From there, they will take care of getting the parcel back to us.
  4. We Receive Your Return

    • It can take anywhere from an estimated 1-10 business days for us to receive your return parcel back to us (depending on location). We check for any returns daily and will process the refund/exchange within 2 business days after receiving the item back to us. We will make sure the entire process is communicated to you once we receive the item back.



Am I Eligible For Free Return Shipping?

If you qualify for free return shipping, our Customer Service Team will make this clear to you in your request. Unfortunately, we are not able to cover return postage fees on all return types.


What Items Are Restricted For Returns*?

We will not accept Change of Mind Returns for the following items:

  • Baby Formula
  • Prescription Medicine
  • Perfumes & Colognes
  • Bulk / Special Orders