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  • SuperNAD+ 150mg 180 Capsules (Nicotinamide Riboside)
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Code: 10048450

SuperNAD+ 150mg 180 Capsules

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Product info

What is NAD+?

Nicotinamide Adenine Dinucleotide (NAD+) is an essential molecule found in every living cell. 

Why is NAD+ so important?

NAD+ plays many roles in our cells but primarily acts as a communication molecule between the cell nucleus and the mitochondria which are the energy-producing factories in the cell. NAD+ is required for essential biological processes including energy creation, regulating circadian rhythms, cholesterol synthesis and maintaining healthy DNA. 1

What Lowers NAD?

As we age, our supply of NAD+ levels decline. If NAD+
levels are low, the communication may be impaired leading to mitochondrial dysfunction. Several disease and lifestyle factors have also been shown to deplete our cellular NAD+ levels. These include: 

•    Ageing
•    Alcohol consumption 2
•    Overnutrition & Obesity 3
•    Sun (UV) damage 4
•    Intense noise exposure leading to hearing loss 5
•    Heart disease 6
•    Neurodegenerative disease 7
•    Changing time zones and night-shift work 8‚Äč

Boosting NAD+ levels promote cellular metabolism, mitochondrial function, and energy production. 

 

How to get more NAD?

Our cells naturally produce NAD+. Maintaining a regular sleep-work schedule, regular exercise, reducing sun exposure and alcohol intake can all help retain and increase those levels. But the cruel reality is NAD+ levels are highest at birth and decreases dramatically with age. As a result, better lifestyle choices alone aren’t always enough to produce the amounts of NAD+ we need for healthy, strong cells. 

 

WHAT IS NICOTINAMIDE RIBOSIDE (NR)? 


Nicotinamide Riboside is a unique food form of vitamin B3 that yields the highest potential in vitro amount of NAD. The Food and Drug Administration (FDA) has also reviewed its safety and has provided it with a ‘Generally Recognised as Safe’ status. 
Furthermore, several human trials have shown Nicotinamide Riboside supplementation can significantly increase NAD levels to those of younger adults. There are also currently 14 ongoing registered clinical trials exploring the potential health benefits of NR supplementation. 
In a randomised, six week, double-blind, placebo-controlled clinical trial, in healthy middle-aged to older adults (n=24), chronic NR supplementation (500 mg, twice/day) for 6 weeks demonstrated positive trends including a reduction in systolic blood pressure and arterial stiffness. 10
An eight-week double-blind, randomised clinical trial (n=118) assessing the efficacy and safety of NR dosed at either 250 mg NR or 500 mg NR versus a placebo control group showed a significant increase in whole blood NAD+ by an average of 40% at four weeks and maintained that increase for the duration of the trial. In addition, potentially positive effects were observed regarding liver function which may become more apparent in larger scale clinical trials. 11


WHAT OTHER NAD+ PRECURSORS DO 


There are two other forms of vitamin B3 that can also increase NAD levels, Niacin (Nicotinic Acid) and Nicotinamide. Niacin can cause painful “flushing” when taken as a supplement. Nicotinamide also adversely inhibits the activity of important “longevity proteins” known as Sirtuins. In comparison, Nicotinamide Riboside may activate Sirtuins, which are associated with cellular metabolism and longevity. 
NICOTINAMIDE RIBOSIDE 
Nicotinamide Riboside has been rigorously tested using internationally accepted safety protocols. It has been issued with the FDA 
‘Generally Recognized As Safe’ (GRAS) status and a New Dietary Ingredient Notification (NDIN).  This compound is listed as a food in the USA as such No serious adverse effects have been reported with the use of Nicotinamide Riboside in studies and as a daily supplement.  


DOSAGE & ADMINISTRATION 


Supplements in the USA contain Nicotinamide Riboside at 150mg-300mg daily with or without food. Taken as a single daily dose preferably in the morning or divided into two doses taken in the morning and early afternoon. 
Super NAD+ capsules are vegetarian safe, gluten-free, nut-free, caffeine-free and contain no animal by-products, or artificial colours and flavours. 
Disclaimer: Nicotinamide riboside is not approved by the TGA 


ADDITIONAL NOTES 


Consult your doctor or pharmacist if you are diabetic, undergoing cancer treatments or suffer from auto-immune disease before taking  NAD supplements. There are some general precautions that must be taken with all Vitamin B3 supplements. 


REFERENCES 

  1. Braidy N, et al. (2018) Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases, Antioxid Redox Signal, doi: 10.1089/ars.2017.7269.
  2. Wang S, et al. (2018) Nicotinamide riboside attenuates alcohol-induced liver injuries, Redox Biology 17:89-98, doi: 10.1016/j.redox.2018.04.006
  3. Cantó C, et al. (2012) The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity, Cell Metab.,15:838–847, doi: 10.1016/j.cmet.2012.04.022
  4. Kauppinen A, et al. (2013) Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders, Cellular Signalling, 25(10):1939-1948, doi: 10.1016/j.cellsig.2013.06.007.
  5. Brown K, et al. (2014) Activation of SIRT3 by the NAD+ Precursor Nicotinamide Riboside Protects from Noise-Induced Hearing Loss, Cell Metabolism, 20(6):1059-1068, doi: 10.1016/j.cmet.2014.11.003
  6. Walker M, Tian R (2018) Raising NAD in Heart Failure, Circulation, 137:2274-2277, doi: 10.1161/CIRCULATIONAHA.117.032626
  7. Yang J, Klaidman LK, Nalbandian A, Oliver J, Chang ML, Chan PH, Adams JD Jr. (2002) The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats. Neurosci Lett 333:91–94.
  8. Nakahata Y, Bessho Y (2016) The Circadian NAD+ Metabolism: Impact on Chromatin Remodeling and Aging, BioMed Research International, doi: 10.1155/2016/3208429
  9. Trammell S, et al. (2016) Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 7:12948, doi: 10.1038/ncomms12948
  10. Martens C, et al. (2018) Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults, Nature Communications, 9:1286, doi: 10.1038/s41467-018-03421-7
  11. Dellinger RW, et al. (2017) Repeat dose NR/PT increases NAD(+) levels in humans safely and sustainably: a randomized, double-blind, placebo controlled study. NPJ Aging Mech Dis 3: 17, doi: 10.1038/s41514-017-0016-9
Delivery info

Please note that Public Holidays will add on extra delivery time for orders

Superpharmacy Orders will be packaged in plain, impervious packaging that is unmarked for security and privacy reasons. Orders will be dispatched as soon as possible once payment is received. 

We will dispatch most orders within business day from Monday to Friday, assuming all items are in stock. All other orders will be dispatched as quickly as possible thereafter.

For Orders containing prescription items please see the prescription processing procedure.

Australia Wide shipment details

We offer Standard Shipping for $4.95** with approximately 3-6 business days of transit time based upon your location within Australia.*

We also offer an Express Delivery Service for $10.95** with approximately 1-3 business days of transit time based upon your location within Australia.*

All Australian orders $99 or more in value (and under 3kgs) will qualify for FREE Standard Shipping or Express Delivery at $7.95

Any orders over 3kgs will have our Online Team be in contact with further information regarding shipping.

All orders of Prescription items will receive FREE Delivery regardless of order value.

*These estimations are based upon transit time once dispatched from our locations. Please note our couriers do not operate on weekends and public holidays.

**These delivery costs do not represent orders that we consider 'Bulk Orders'.  Bulk Orders will have our Online Team be in touch in order to discuss appropriate shipping costs. For clarification on what we classify as a 'Bulk Order', refer to our terms and conditions or give us a call.

 

PRESCRIPTION PROCESSING PROCEDURE

Orders for prescription items can only be processed once we physically receive your prescription paperwork. Prescription product orders will be dispensed and dispatched on the business day the prescription or valid repeat authorisation is received at the SUPERPHARMACY registered premises. Please send your prescription paperwork to the appropriate store

NSW, NT and TAS:  SUPERPHARMACY PO Box 1877 Hornsby Westfield 1635

QLD: Superpharmacy 187 Days Road, Grange QLD 4051

SA: Superpharmacy 41 Hindley Street, Adelaide SA 5000

VIC: Superpharmacy 92 Lygon Street, East Brunswick VIC 3057

WA: Superpharmacy 259 Walcott Street, North Perth WA 6006

Ensure to allow sufficient time for the delivery of your prescription or repeat authorisation paperwork to us and the subsequent order delivery via our specialised delivery network. We recommend considering a total of up to 7 days for metro areas or 10 days in remote areas. If we do not already hold your prescription paperwork, it will be necessary for you to send the prescription paperwork to us before we can dispatch your order. Please also allow the appropriate time for the prescription to reach us and for the order to be sent back so as to avoid running out of your ongoing prescription medicine.

We partner with well-known and trusted delivery services to minimise delivery times. These include:

  • Our own personal delivery driver
  • StarTrack
  • Auspost
  • Local delivery couriers

The end goal is to get your order to you as fast and as securely as possible.

Details of the delivery process and conditions are included in the Superpharmacy Terms and Conditions found here

It may be necessary for some orders to be shipped in more than one box from different distribution sites and therefore you may obtain these parcels at different times. We will notify you via email if there is a delay in the delivery of an item in your Order and what action we have taken.

Order processing and delivery times may vary in peak times with special arrangements during peak volume times such as Christmas, Mother's Day and Superpharmacy promotions. Contact our Customer Service on 1300 4MEDICINE during business hours or email customerservice@superpharmacy.com.au for more information.

Postage and handling for international orders

We do not currently deliver outside of Australia 

Returns & exchanges

How Do Returns & Refunds Work?


We are happy to offer refunds or exchanges on any item (excluding restricted items*) that you have purchased from us.

Important: You are not entitled to, or guaranteed, a refund for Change of Mind returns. They will be processed at our discretion. We reserve the right to charge a restocking fee for Change of Mind returns.
You will be responsible for the cost of shipping to return goods to us unless we specify that we will cover the cost.

Note: Legislation prohibits us from accepting Prescription Items for refund or exchange.

 

All we ask is that you follow the below to qualify:

  1. Check your products as soon as you receive delivery. Ensure the correct items have been sent, and nothing is damaged or in an unusable condition.
     
  2. Contact us within 30 days from your order date (7 days for damaged/incorrect items).
     

How We Handle Them:
 

Change of Mind

  • If you've had a change of mind about an item you have ordered, we'll need to receive it back to us unopened and unused, in the original packaging.
     

Faulty Item

  • If the item you have received is faulty, please contact us with a detailed description of the product fault, alongside a photo if possible.

 

Allergic Reaction

  • In the rare instance you've had an allergic reaction to a product, please discontinue use of the product immediately. We may reach out for further information on the reaction.

Allergy returns must be less than 20% used upon arrival back to us.
 

Incorrect / Damaged Items

  • If you have received an item that isn't what you ordered, or it arrived damaged, please take a photo and contact us within 7 days of delivery. 

Please don't dispose of the item without informing us.

 

The Process:

  1. Contact Us

    • To start a return, please send your request to customerservice@superpharmacy.com.au. Make sure we have received & acknowledged your request before you send the item back to us.
       
  2. Instructions

    • A Customer Service Team Member will then review your request, and be in touch with some further information. Should your request be approved, they will supply a return address for you to post the item back to us, and instructions on how to do so.
       
  3. Drop Off At Your Post Office

    • Once you have received the returns address and packaged and labelled your box as instructed, all you need to do is drop off the parcel at your local Post Office. From there, they will take care of getting the parcel back to us.
       
  4. We Receive Your Return

    • It can take anywhere from an estimated 1-10 business days for us to receive your return parcel back to us (depending on location). We check for any returns daily and will process the refund/exchange within 2 business days after receiving the item back to us. We will make sure the entire process is communicated to you once we receive the item back.

 

 

Am I Eligible For Free Return Shipping?

If you qualify for free return shipping, our Customer Service Team will make this clear to you in your request. Unfortunately, we are not able to cover return postage fees on all return types.

 

What Items Are Restricted For Returns*?

We will not accept Change of Mind Returns for the following items:

  • Baby Formula
  • Prescription Medicine
  • Perfumes & Colognes
  • Bulk / Special Orders

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