Age related illnesses | May 15, 2019 | Author: Naturopath
Alzheimer’s disease (AD) is a frightening disorder under the umbrella term of Dementia. There are a number of different hypothesis of what causes it, with ageing, genetics and inflammation being most probable influences. Prevention is one thing, but how to help once a diagnosis is made.
One scientifically proven is supportive measure is to increase nutrient intake. This can be hard as the amount of nutrition needed to help is more than could possible be consumed. Ensuring a healthy diet is always important, and along with eating nutrient dense foods, supplementing can make a difference.
Souvenaid is a medical drink which contains nutrients found to be supportive of memory function in the early stages of Alzheimer’s disease. The nutrients contained include:
These nutrients in Souvenaid supports brain phospholipid metabolism.
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The brain receives sensory input, integrates new and stored information, makes decisions and is responsible for motor activity (movement of the body), supporting your body in its efforts towards homeostasis (physical and chemical balance).
The brain is the portion of the central nervous system found in the cranium. It consists of approximately 100 billion neurons. A neuron, or nerve cell, is an electrically excitable cell which is able to communicate with other cells. It does this via specific connections called synapses.
A neuron forms about 1000 synapsis with other neurons.
This process is continuous through life and dependant on three main nutrients. Uridine, DHA – omega 3 fatty acid and choline.
These nutrients together help accelerate the formation of synaptic membrane (the major component of synapses).
Souvenaid nutritionally supports these synaptic connections.
The brain is the centre for intelligence, for emotion, behaviour and memory, and is divided by different regions, each specialized for differing functions. Blood flows via the internal carotid and vertebral arteries, delivering oxygen and glucose to fuel the brain, needed even at rest. Glucose has to be continuously supplied to the brain, as its ability is storage is limited to non-existent. When the blood to the brain is low in glucose, mental confusion, dizziness, convulsions and loss of consciousness will occur.
The blood-brain barrier (BBB) protects the brain cells from harmful substances, but allows glucose and a few other water-soluble substances to pass through. Other substances cross the BBB very slowly and other substances not at all. Lipid-soluble substances pass easily. Trauma, inflammation and toxins can result in a breakdown of the BBB.
Alzheimer’s disease (AD) is a disabling senile dementia which results in the inability to care for one’s self. The exact cause of most cases of AD is generally unknown, with evidence suggesting aging, genetic factors, environmental factors and lifestyle playing a role in its development.
Three distinct structural abnormalities
1. Loss of neurons that release acetylcholine (a chemical in the brain which functions as a neurotransmitter (a chemical messenger released by the nerve cells to signals to other cells). This is a hallmark of AD.
2. Beta-amyloid plaques (clusters of abnormal proteins deposited outside of the neurons).
3. Neurofibrillary tangles (abnormal bundles of filaments inside neurons in affected parts of the brain).
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AD patients are often malnourished and have a number of nutrient deficiencies particularly vitamin B-group vitamins and vitamin D. Cross-sectional studies revealed nutrient intake being significantly lower of macronutrients, calcium, iron, zinc, vitamin K, vitamin A, fibre, omega 3 and 6 fatty acids.
Phospholipids are types of lipid molecules which form the cell membrane. They are able to do this because their phosphate head is hydrophilic (water attracting), whilst their fatty acid tails are hydrophobic (water repellent). This allows fat-soluble substances, including vitamins and lipids, to pass easily in and out of the cell. Found in lecithin and lecithin containing foods like eggs, soybeans, wheat germ and peanuts.
Choline is an essential nutrient for humans as building block for phospholipid membranes and acetylcholine. Dietary intake of choline is thought to influence cognitive function via EPA and DHA. Choline is believed to be neuroprotective of neuronal damage. Foods containing high amounts of choline include: beef pate, egg yolk, braised beef and roasted soybeans.
Aging can result in depletion of important long chain omega-3 fatty acids.
Fatty acids make-up 30-35% of the brain (obviously important), loss of which can can lead to neurodegenerative conditions such as AD. These long chain fatty acids are concentrated in the phospholipid membrane of the brain – particularly the synapses. EPA and DHA are absolutely essential for normal function of the brain.
The brains of AD patients have been found to contain lower amounts of these essential fatty acids. Fish oil is also known to help reduce inflammation, associated with AD development.
Uridine monophosphate. Uridine is a naturally occurring nucleic acid which is involved in many neuroregulatory processes, phospholipid synthesis, acts as a neurotransmitter, is neuroprotective, increases phosphatidylcholine levels and is involved in the mediation of memory and learning, amongst other things. In infancy Uridine monophosphate is supplied to the baby through breast milk, but in adulthood uridine is synthesized by the liver. Uridine monophosphate works in synergy with choline, DHA and other phospholipids.
Souvenaid can be effective in mild Alzheimer’s disease in as soon as 4 weeks of supplementation.
Supporting memory performance and improvements in verbal recall in patients at early stages of AD.
Souvenaid is an easy to take liquid formula which may be taken straight from the bottle through a straw, alternatively pour and drink from a glass.
Take one Souvenaid drink once a day. Try taking it at the same time each day so it becomes a habit.
Tortora, Gerald J and Derrickson, Bryan 2006 Principles of Anatomy and Physiology 11th edition, John Wiley and sons, Inc, USA
Why neurons die: cell death in the nervous system. https://www.ncbi.nlm.nih.gov/pubmed/9700393
Effect Size Analyses of Souvenaid in Patients with Alzheimer's Disease. https://www.ncbi.nlm.nih.gov/pubmed/27767993
The medical food Souvenaid affects brain phospholipid metabolism in mild Alzheimer’s disease: results from a randomized controlled trial. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5530581/
Tolerability and safety of Souvenaid in patients with mild Alzheimer's disease: results of multi-center, 24-week, open-label extension study. https://www.ncbi.nlm.nih.gov/pubmed/25322923
The efficacy of supplementation with the novel medical food, Souvenaid, in patients with Alzheimer's disease: A systematic review and meta-analysis of randomized clinical trials. https://www.ncbi.nlm.nih.gov/pubmed/26638900
Omega-3 Fatty Acids in Early Prevention of Inflammatory Neurodegenerative Disease: A Focus on Alzheimer's Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537710/
Modulating Effect of Diet on Alzheimer’s Disease https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473547/
Neuroprotective Actions of Dietary Choline https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579609/
Normal and Clinical Nutrition 6th Edition, Wadsworth/Thompsons Learning, Australia
A Nutrient Combination that Can Affect Synapse Formation https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011061/